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SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7
USERS' SCORE
Good
Based on 1 Review
8.6
Supplement Facts
Serving Size: 3 Veg Capsules
Amount Per Serving
%DV
Magnesium (elemental) (from 2,667 mg Magnesium Citrate)
400 mg
95%
Top Medical Research Studies
8
Magnesium nanoparticles inhibit cancer growth
Magnesium whitlockite nanoparticles: Hydrothermal synthesis, anti-inflammatory and anti-cancer potential.
Direct relevance to breast cancer
We investigated the effects of magnesium whitlockite nanoparticles, or WH NPs, and their potential role in combating breast cancer. By synthesizing these nanoparticles and exploring their various properties, we aimed to understand how they could influence inflammation and cancer cell growth.
Our detailed analyses revealed that WH NPs are derived from brushite with magnesium ions introduced during a hydrothermal process. In the context of breast cancer, we observed that these nanoparticles exhibited notable anti-cancer activity by effectively inhibiting the proliferation of MDA-MB-231 breast cancer cells.
Additionally, WH NPs demonstrated anti-inflammatory effects, significantly lowering the production of important markers associated with inflammation. This dual action of reducing inflammation and targeting cancerous cells suggests a promising avenue for innovative treatments in the fight against breast cancer.
Our detailed analyses revealed that WH NPs are derived from brushite with magnesium ions introduced during a hydrothermal process. In the context of breast cancer, we observed that these nanoparticles exhibited notable anti-cancer activity by effectively inhibiting the proliferation of MDA-MB-231 breast cancer cells.
Additionally, WH NPs demonstrated anti-inflammatory effects, significantly lowering the production of important markers associated with inflammation. This dual action of reducing inflammation and targeting cancerous cells suggests a promising avenue for innovative treatments in the fight against breast cancer.
Read More
8
MeJa stimulates magnesium-induced apoptosis
Methyl Jasmonate-induced Increase in Intracellular Magnesium Promotes Apoptosis in Breast Cancer Cells.
Direct link to magnesium in cancer
We explored the effects of methyl jasmonate (MeJa), a plant hormone, on breast cancer cells, specifically looking at how it influences intracellular magnesium levels and cell death. Our study used the MCF-7 breast cancer cell line to analyze these interactions.
In our approach, we assessed cell viability through an MTT assay and measured magnesium concentrations using advanced spectrophotometry. We also looked at how MeJa affects ATP levels, reactive oxygen species (ROS), and the MAPK signaling pathway, which are all crucial in understanding cancer cell behavior.
We found that increased magnesium levels led to reduced expression of TRPM7, a magnesium transporter, which directly correlated with higher ROS production and signs of stress in the cell. As a result, we observed that these changes contributed to increased apoptosis, or programmed cell death, in the breast cancer cells.
Ultimately, our findings suggest that manipulating magnesium levels might provide a novel pathway through which MeJa promotes cell death in breast cancer, offering insight into potential treatment strategies.
In our approach, we assessed cell viability through an MTT assay and measured magnesium concentrations using advanced spectrophotometry. We also looked at how MeJa affects ATP levels, reactive oxygen species (ROS), and the MAPK signaling pathway, which are all crucial in understanding cancer cell behavior.
We found that increased magnesium levels led to reduced expression of TRPM7, a magnesium transporter, which directly correlated with higher ROS production and signs of stress in the cell. As a result, we observed that these changes contributed to increased apoptosis, or programmed cell death, in the breast cancer cells.
Ultimately, our findings suggest that manipulating magnesium levels might provide a novel pathway through which MeJa promotes cell death in breast cancer, offering insight into potential treatment strategies.
Read More
8
Magnesium's role in breast cancer
Evaluation of biogenically synthesized MgO NPs anticancer activity against breast cancer cells.
High relevance to study topic
We observed the potential of magnesium oxide nanoparticles (MgO NPs) in fighting breast cancer, particularly against the MDA-MB-231 cell line. Through a variety of biological tests—like measuring how these nanoparticles affect cell survival, induce cell death, and cause oxidative stress—we aimed to determine their effectiveness as a treatment option.
Our findings showed that MgO NPs significantly increased cytotoxic effects, leading to cell death. Not only did we see a rise in reactive oxygen species (ROS) production, but we also noted improved cell adhesion and decreased cellular migration, suggesting that these nanoparticles might hinder cancer progression in a measurable way.
While these results are promising, we recognize that further studies, including research on animal models or human trials, are necessary. Validating these findings in more complex systems will be crucial for confirming MgO NPs as a viable cancer treatment.
Our findings showed that MgO NPs significantly increased cytotoxic effects, leading to cell death. Not only did we see a rise in reactive oxygen species (ROS) production, but we also noted improved cell adhesion and decreased cellular migration, suggesting that these nanoparticles might hinder cancer progression in a measurable way.
While these results are promising, we recognize that further studies, including research on animal models or human trials, are necessary. Validating these findings in more complex systems will be crucial for confirming MgO NPs as a viable cancer treatment.
Read More
Most Useful Reviews
9.5
Immune system support
I buy magnesium citrate for my mother, who has blood cancer, specifically multiple myeloma. During her treatment, including chemotherapy and a bone marrow transplant, it was essential to maintain her immunity. A dietary supplement combining vitamins D3, K2, B6, magnesium citrate, and colostrum has proven effective. Additionally, magnesium citrate has helped with sleep and normalising her stool. One capsule at bedtime for a year has stabilised her condition, keeping biochemistry readings normal and boosting her immune system to help combat cancer cells.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7
8
Magnesium nanoparticles inhibit cancer growth
Magnesium whitlockite nanoparticles: Hydrothermal synthesis, anti-inflammatory and anti-cancer potential.
Direct relevance to breast cancer
We investigated the effects of magnesium whitlockite nanoparticles, or WH NPs, and their potential role in combating breast cancer. By synthesizing these nanoparticles and exploring their various properties, we aimed to understand how they could influence inflammation and cancer cell growth.
Our detailed analyses revealed that WH NPs are derived from brushite with magnesium ions introduced during a hydrothermal process. In the context of breast cancer, we observed that these nanoparticles exhibited notable anti-cancer activity by effectively inhibiting the proliferation of MDA-MB-231 breast cancer cells.
Additionally, WH NPs demonstrated anti-inflammatory effects, significantly lowering the production of important markers associated with inflammation. This dual action of reducing inflammation and targeting cancerous cells suggests a promising avenue for innovative treatments in the fight against breast cancer.
Our detailed analyses revealed that WH NPs are derived from brushite with magnesium ions introduced during a hydrothermal process. In the context of breast cancer, we observed that these nanoparticles exhibited notable anti-cancer activity by effectively inhibiting the proliferation of MDA-MB-231 breast cancer cells.
Additionally, WH NPs demonstrated anti-inflammatory effects, significantly lowering the production of important markers associated with inflammation. This dual action of reducing inflammation and targeting cancerous cells suggests a promising avenue for innovative treatments in the fight against breast cancer.
Read More
8
Magnesium-curcumin complex shows promise
The Antitumoral Effect In Ovo of a New Inclusion Complex from Dimethoxycurcumin with Magnesium and Beta-Cyclodextrin.
Focus on magnesium-curcumin complex
We explored how a new inclusion complex made from dimethoxycurcumin and magnesium influences breast cancer cell behavior, particularly in the context of MDA-MB-231 cells, a line known for its aggressiveness. The study demonstrated that this new compound, which was combined with beta-cyclodextrin to enhance solubility, significantly altered cell metabolism and morphology, slowed cell migration, and induced apoptosis in cancer cells.
Importantly, the complex also reduced levels of specific inflammatory markers and transcription factors linked to cancer aggression. When tested in an in ovo model, we observed that this magnesium-curcumin complex could inhibit tumor growth by up to 30%. In contrast, the free magnesium complex demonstrated a lesser inhibition of 17.29%, showcasing the enhanced efficacy of the inclusion complex form.
Overall, while magnesium in isolation wasn't the focus, our findings suggest that the magnesium-curcumin inclusion complex offers promising therapeutic potential against breast cancer, particularly due to its improved solubility and effectiveness.
Importantly, the complex also reduced levels of specific inflammatory markers and transcription factors linked to cancer aggression. When tested in an in ovo model, we observed that this magnesium-curcumin complex could inhibit tumor growth by up to 30%. In contrast, the free magnesium complex demonstrated a lesser inhibition of 17.29%, showcasing the enhanced efficacy of the inclusion complex form.
Overall, while magnesium in isolation wasn't the focus, our findings suggest that the magnesium-curcumin inclusion complex offers promising therapeutic potential against breast cancer, particularly due to its improved solubility and effectiveness.
Read More
8
MeJa stimulates magnesium-induced apoptosis
Methyl Jasmonate-induced Increase in Intracellular Magnesium Promotes Apoptosis in Breast Cancer Cells.
Direct link to magnesium in cancer
We explored the effects of methyl jasmonate (MeJa), a plant hormone, on breast cancer cells, specifically looking at how it influences intracellular magnesium levels and cell death. Our study used the MCF-7 breast cancer cell line to analyze these interactions.
In our approach, we assessed cell viability through an MTT assay and measured magnesium concentrations using advanced spectrophotometry. We also looked at how MeJa affects ATP levels, reactive oxygen species (ROS), and the MAPK signaling pathway, which are all crucial in understanding cancer cell behavior.
We found that increased magnesium levels led to reduced expression of TRPM7, a magnesium transporter, which directly correlated with higher ROS production and signs of stress in the cell. As a result, we observed that these changes contributed to increased apoptosis, or programmed cell death, in the breast cancer cells.
Ultimately, our findings suggest that manipulating magnesium levels might provide a novel pathway through which MeJa promotes cell death in breast cancer, offering insight into potential treatment strategies.
In our approach, we assessed cell viability through an MTT assay and measured magnesium concentrations using advanced spectrophotometry. We also looked at how MeJa affects ATP levels, reactive oxygen species (ROS), and the MAPK signaling pathway, which are all crucial in understanding cancer cell behavior.
We found that increased magnesium levels led to reduced expression of TRPM7, a magnesium transporter, which directly correlated with higher ROS production and signs of stress in the cell. As a result, we observed that these changes contributed to increased apoptosis, or programmed cell death, in the breast cancer cells.
Ultimately, our findings suggest that manipulating magnesium levels might provide a novel pathway through which MeJa promotes cell death in breast cancer, offering insight into potential treatment strategies.
Read More
8
Magnesium's role in breast cancer
Evaluation of biogenically synthesized MgO NPs anticancer activity against breast cancer cells.
High relevance to study topic
We observed the potential of magnesium oxide nanoparticles (MgO NPs) in fighting breast cancer, particularly against the MDA-MB-231 cell line. Through a variety of biological tests—like measuring how these nanoparticles affect cell survival, induce cell death, and cause oxidative stress—we aimed to determine their effectiveness as a treatment option.
Our findings showed that MgO NPs significantly increased cytotoxic effects, leading to cell death. Not only did we see a rise in reactive oxygen species (ROS) production, but we also noted improved cell adhesion and decreased cellular migration, suggesting that these nanoparticles might hinder cancer progression in a measurable way.
While these results are promising, we recognize that further studies, including research on animal models or human trials, are necessary. Validating these findings in more complex systems will be crucial for confirming MgO NPs as a viable cancer treatment.
Our findings showed that MgO NPs significantly increased cytotoxic effects, leading to cell death. Not only did we see a rise in reactive oxygen species (ROS) production, but we also noted improved cell adhesion and decreased cellular migration, suggesting that these nanoparticles might hinder cancer progression in a measurable way.
While these results are promising, we recognize that further studies, including research on animal models or human trials, are necessary. Validating these findings in more complex systems will be crucial for confirming MgO NPs as a viable cancer treatment.
Read More
8
Magnesium complexes show anticancer promise
Hybrid Inorganic Complexes as Cancer Therapeutic Agents: In-vitro Validation.
Study lacks focus on isolated magnesium
We examined a series of mixed transition metal-magnesium complexes to understand their potential as cancer-fighting agents, particularly in breast cancer. The focus was on how these compounds, specifically the cobalt and copper magnesium tartarate complexes, affected the MDA-MB-231 breast cancer cell line.
The complexes were carefully synthesized and characterized through various analytical methods. We found that both the cobalt (C3) and copper (C5) complexes showed promising results, displaying significant antiproliferative activity when tested at a concentration of 200 µg/ml. Notably, these complexes not only inhibited cell growth but also reduced cell migration in the cancer cells.
Although the study emphasized the magnesium's role through its coordination in these complexes, it is important to note that the direct impact of isolated magnesium treatment was not specifically addressed. Therefore, while we witnessed a positive outcome with these hybrid complexes, more targeted research is necessary to clarify magnesium's individual contributions.
The complexes were carefully synthesized and characterized through various analytical methods. We found that both the cobalt (C3) and copper (C5) complexes showed promising results, displaying significant antiproliferative activity when tested at a concentration of 200 µg/ml. Notably, these complexes not only inhibited cell growth but also reduced cell migration in the cancer cells.
Although the study emphasized the magnesium's role through its coordination in these complexes, it is important to note that the direct impact of isolated magnesium treatment was not specifically addressed. Therefore, while we witnessed a positive outcome with these hybrid complexes, more targeted research is necessary to clarify magnesium's individual contributions.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Immune system support
I buy magnesium citrate for my mother, who has blood cancer, specifically multiple myeloma. During her treatment, including chemotherapy and a bone marrow transplant, it was essential to maintain her immunity. A dietary supplement combining vitamins D3, K2, B6, magnesium citrate, and colostrum has proven effective. Additionally, magnesium citrate has helped with sleep and normalising her stool. One capsule at bedtime for a year has stabilised her condition, keeping biochemistry readings normal and boosting her immune system to help combat cancer cells.
Read More
